Controversies in anaesthesia - designer drugs
Henderson F, Kenny GN.
University Department of Anaesthesia,
Glasgow Royal Infirmary, UK.
Ann Acad Med Singapore. 1999 May;28(3):434-9.


In the past, the discovery of new drugs often occurred by chance. Over recent years, an increasing knowledge of the mode of drug action and receptor sites has improved our ability to design new drugs. While the mode of action of volatile and intravenous anaesthetic agents remains unclear, neuromuscular blocking agents and opioids have undergone considerable development and design. Drugs are being tailored to produce fewer side effects and to improve desirable properties. As a result, the introduction of new drugs has helped to improve techniques in anaesthesia. The development of remifentanil is an example of this which is discussed. The application of modern technology with target controlled infusions (TCI) for the administration of remifentanil represents further advancement in techniques which may become available to anaesthetists in the future.
Nitrous oxide
Inhaled anaesthetics
Obstetric anaesthesia
Molecular mechanisms
The spongia somnifera
Chloroform anaesthesia
'My beloved chloroform'
'The secularisation of pain'
History of anaesthesia apparatus
Consciousness, anaesthesia and anaesthetics

and further reading
Future Opioids
BLTC Research
Utopian Surgery?
The Good Drug Guide
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World