Eduard C. H. von Siebold: "The use of sulfur ether vapor in obstetrics" (1847). A contribution to the beginning of modern obstetric analgesia and anesthesia in Germany
Wulf H.
Klinik fur Anasthesiologie und Operative Intensivmedizin,
Christian-Albrechts-Universitat zu Kiel.
Anaesthesist. 1998 Jun;47(6):496-500.


In 1847 J.Y. Simpson in Scotland was the first to describe the administration of ether for analgesia in painful deliveries. Only a few days later E.C.J. von Siebold (1801 in Wurzburg-1861 in Gottingen) performed the first systematic study on ether in obstetrics. Following a preceding evaluation of the action of ether on non-pregnant woman and on pregnant women not in active labour, he administered ether for analgesia during the second stage of labour in eight parturients. The first administration was on February 25th 1847. While he was satisfied with the good analgesia without sequelae of the new-born, he was discouraged by the termination of uterine contractions observed in all his patients. He concluded that ether was not a useful substance for analgesia during vaginal delivery, since it disturbed the natural course of labour. On the other hand, von Siebold was very pleased with the administration of ether for operative obstetric procedures such as forceps deliveries or placental retention.
James Simpson
William Morton
John Collins Warren
Chloroform sniffing
Obstetric anaesthesia
Molecular mechanisms
Crawford Williamson Long
Anaesthesia/16th October 1846

and further reading
Future Opioids
BLTC Research
Utopian Surgery?
The Good Drug Guide
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World