Medical history: seishu hanaoka and his success in breast cancer surgery under general anesthesia two hundred years ago
Izuo M.
2-13-6, Onokosei, Shiga-cho,
Shiga Pref.,
520-0532, Japan.
Breast Cancer. 2004;11(4):319-24


In 1804, Seishu Hanaoka performed the first successful surgical treatment of breast cancer under general anesthesia in the world. It preceeded by 38 years C W Long's trial of ether anesthesia in 1842. In this paper, Hanaoka's biography and his contributions to surgery and anesthesiology in those days, and also his advanced ideas about medicine and sanitation are presented. Hanaoka had made many efforts to develop the optimal prescriptionof the anesthetic " Tsusensan(or Mafutsu-To)" for almost 20 years. Finally, he succeeded in using it clinically for breast cancer surgery, on October 13, 1804. Hanaoka performed operations for breast cancer in a total of 156 cases, and also for many other kinds of surgical procedures. He also eagerly contrived and modified many surgical instruments. In spite of such a busy daily schedule, he eagerly trained and educated many students, using his own philosophy for medical management. Details of his background and some discussion from a present-day viewpoints are included.
"Mayaku Ko"
Goda Daisuke
Seishu Hanaoka
General anaesthetics
Recipe for the first general anaesthetic?
Goda Daisuke and "Komo Ijutsu Monsho"
First use of anaesthetics in different countries
Name list of Hanaoka's breast cancer patients
Anaesthesia pioneer Seishu Hanaoka's family tree
Seishu Hanaoka and Shutei Nakagawa's "Mayaku-ko"
Death dates of Hanaoka's patients with breast cancer
Seishu Hanaoka (1760-1835): the poineer of general anaesthesia
Japanese poineer Seishu Hanaoka developed first general anaesthetic

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