General anaesthetics inhibit the responses induced by
glutamate receptor agonists in the mouse cortex
Carla V, Moroni F.
Department of Preclinical and Clinical Pharmacology,
University of Florence, Italy.
Neurosci Lett. 1992 Oct 26;146(1):21-4
ABSTRACTThe effects of several general anaesthetics on the responses evoked by the excitatory amino acid agonists N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) were investigated in mouse cortical wedges placed in a two compartment bath and superfused with a nominally Mg(2+)-free Krebs solution. Chloroform (3-6 mM) and halothane (1-3 mM) preferentially antagonized AMPA responses; thiopental (0.1-0.4 mM), diethyl ether (10-30 mM) and isoflurane (1-3 mM) antagonized both AMPA or NMDA responses while ketamine antagonized NMDA responses in a highly selective way. The antagonism of the excitatory amino acid responses exerted by the anaesthetics was non competitive in nature. The inhibition of excitatory amino acid receptor function may be one of the mechanisms whereby general anaesthesia is produced.People
'My beloved chloroform'
'The secularisation of pain'
Obstetric anaesthesia/John Snow
Volatile anesthetics and NMDA glutamate receptors
and further reading
The Good Drug Guide
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World