Japanese physician Seishu Hanaoka was the father of anaesthesia. He developed and used an orally administered general anaesthetic, a herbal concoction known as "Tsusensan". Hanaoka successfully operated on over 150 patients.
The Doctor's Wife
Japan's Seishu Hanaoka
Refs and Further Reading
The Wife of Seishu Hanaoka
Anaesthesia and Anaesthetics
Hanaoka's technique of breast cancer excision
Japanese poineer Seishu Hanaoka developed first general anaesthetic