Ketamine dependence
Pal HR, Berry N, Kumar R, Ray R.
De-addiction Centre,
All India Institute of Medical Sciences,
New Delhi.
Anaesth Intensive Care. 2002 Jun;30(3):382-4


Ketamine hydrochloride is a safe and rapid-acting non-opioid, lipid soluble anaesthetic with a short elimination half-life that is used for medical and veterinary purposes. It produces a state of "dissociative anaesthesia", probably from action on N-methyl-D-aspartate (NMDA) receptors. The psychotropic effects of ketamine range from dissociation and depersonalization to psychotic experiences and include a sensation of feeling light, body distortion, absence of time sense, novel experiences of cosmic oneness and out-of-body experiences. Abuse of ketamine has been reported, the typical abuser being an individual who uses multiple drugs and has some contact with medical agencies. This case demonstrates the effects of large doses of ketamine in a person with polysubstance abuse. The case also highlights development of significant tolerance to ketamine without prominent withdrawal symptoms. Caution in use of ketamine is reiterated in light of its abuse liability.
Adverse effects
Ketamine in Nepal
Obstetric anaesthesia
Molecular mechanisms
Inhalational techniques
Ketamine - dreams and realities
Anaesthesia: rivalries and discoveries
Antihyperalgesic effect of low dose ketamine
Consciousness, anaesthesia and anaesthetics
Volatile anesthetics and NMDA glutamate receptors

and further reading
Future Opioids
BLTC Research
Utopian Surgery?
The Good Drug Guide
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World