Frostbite of the face after recreational
misuse of nitrous oxide

Hwang JC, Himel HN, Edlich RF.
Department of Anesthesiology,
University of Virginia,
School of Medicine,
Charlottesville, USA.
Burns. 1996 Mar;22(2):152-3.


Exposure of the skin to nitrous oxide, a liquified gas stored under pressure in a cylinder, can occur in anaesthesiologists and in those involved in recreational misuse of the gas. A case is reported of a man who presented to the emergency department after sniffing nitrous oxide and sustaining frostbite injury to his left cheek. Conservative management of this injury allowed spontaneous separation of the necrotic tissue and healing of the granulating wound by contraction.
Nitrous oxide
Inhaled anaesthetics
Rats on nitrous oxide
Nitrous oxide inhalation
Nitrous oxide plus ethanol
Nitrous oxide and marijuana
Nitrous oxide: 'laughing gas'
Nitrous oxide and the opioid receptors
Beta-endorphin/nitrous oxide withdrawal
Nitrous oxide - subjective and rewarding effects
Whipped cream bulbs cause nitrous oxide myelopathy

and further reading
Future Opioids
BLTC Research
Utopian Surgery?
The Good Drug Guide
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World