Schizophrenia, dissociative anaesthesia and near-death experience;
three events meeting at the NMDA receptor
Department of Pharmacology,
Erasmus University Rotterdam,
Med Hypotheses. 2004;62(1):23-8
ABSTRACTThe three events, viz. schizophrenia, dissociative anaesthesia and Near-Death Experience, despite their seemingly unrelated manifestation to each other, have nevertheless similar functional basis. All three events are linked to the glutamate sensitive N-methyl-D-aspartate (NMDA) receptor complex, which serves as their common functional denominator. Arguments and speculations are presented in favor of the view that, the three events might be considered as functional models of each other. Antagonism to the recognition NMDA-site of the receptor induces dissociative anaesthesia and precipitates Near-Death Experience. Agonist reinforcement at the modulatory glycine-site of the receptor counteracts negative symptoms of schizophrenia. Both types of challenges towards the receptor are compatible with a glutamate deficiency concept which underlies the meeting of the three events at the NMDA receptor.People
'My beloved chloroform'
'The secularisation of pain'
Obstetric anaesthesia/John Snow
Volatile anesthetics and NMDA glutamate receptors
and further reading
The Good Drug Guide
The Abolitionist Project
The Hedonistic Imperative
The Reproductive Revolution
Critique of Huxley's Brave New World